HPLC and LC-MS: Different Questions, Complementary Tools

What HPLC tells you

High-performance liquid chromatography separates components under defined analytical conditions. It can be used to examine a sample profile and report chromatographic purity.

A purity percentage depends on the method and how peaks are detected and integrated. It is not a universal measurement of every possible contaminant.

What LC-MS adds

Liquid chromatography coupled with mass spectrometry provides mass-related information that can support compound identification. It addresses a different question from chromatographic purity alone.

Review the expected molecular information and the actual report rather than assuming that the presence of a method name guarantees a complete characterization.

Interpret the methods together

Identity and purity are complementary parts of material assessment. Neither should be replaced by packaging, appearance or an unqualified claim of premium quality.

For each ZYNOR product, consult its own documentation. The catalog lists different analytical information for different compounds; do not assume every item has identical testing.

Know the limits

Analytical characterization does not establish clinical safety, sterility or efficacy. Additional tests may be required for a specific laboratory project.

These materials are for in-vitro research only and are not intended for human or animal use.